2.2.1 is a hotfix for one bug that shipped with 2.2.0.
If a Keyboard module was set to the Neon design, the first note you held made every Keyboard panel in your layout stop drawing and show "Paused after an error". Hitting "Try again" brought them back until the next note. The other seven keyboard designs were never affected, and neither was anything else in the app.
Neon's drawing code asked for the wrong thing at the moment a key went down, which is why the design looked perfectly normal while nothing was playing. It now asks for the key it is actually drawing, which is also the correct answer for a chord played on a single MIDI channel.
Nothing to do on your side: Steam updates the build for you.