Endless Descent

1. 
   First Blood

   Kill your first enemy.
   100%
2. 
   Exterminator

   Kill 100 enemies.
   62%
3. 
   Slayer

   Kill 500 enemies.
   38%
4. 
   Genocide

   Kill 1,000 enemies.
   38%
5. 
   Damage Dealer

   Deal 10,000 total damage.
   38%
6. 
   Heavy Hitter

   Deal 50,000 total damage.
   38%
7. 
   Boss Slayer

   Defeat your first boss.
   100%
8. 
   Boss Hunter

   Defeat 10 bosses.
   46%
9. 
   Boss Executioner

   Defeat 25 bosses.
   46%
10. 
    Slime Nemesis

    Defeat the Mother Slime boss.
    46%
11. 
    Giant Killer

    Defeat the rock boss.
    15%
12. 
    Dragon Slayer

    Defeat the Dragon boss.
    23%
13. 
    Critical Strike Master

    Land 100 critical hits.
    31%
14. 
    Combo Master

    Achieve a 50-hit combo.
    31%
15. 
    Weapon Master

    Kill enemies with 10 different weapon types.
    23%
16. 
    Survivor

    Complete a floor without dying.
    100%
17. 
    Iron Will

    Survive 10 floors without your health falling below 50%
    77%
18. 
    Legendary Survivor

    Survive 25 floors without your health falling below 50%.
    7.6%
19. 
    Low Health Hero

    Complete a floor with less than 10% health.
    92%
20. 
    Potion Master

    Use 100 health potions.
    31%
21. 
    Shield Bearer

    Block 500 attacks successfully.
    0.0%
22. 
    Dodge Master

    Dodge 1,000 attacks.
    0.0%
23. 
    Death Defier

    Survive with 1 HP 5 times.
    31%
24. 
    Comeback Kid

    Heal from 1% to 100% health in a single floor.
    100%
25. 
    Tank

    Take 25,000 total damage.
    31%
26. 
    Treasure Hunter

    Open 100 chests.
    62%
27. 
    Treasure Master

    Open 500 chests.
    38%
28. 
    Secret Keeper

    Find 50 secret areas.
    62%
29. 
    Explorer

    Find 100 secret areas.
    54%
30. 
    Wealthy

    Accumulate 10,000 total Ash.
    38%
31. 
    Rich

    Accumulate 50,000 total Ash.
    38%
32. 
    Soulstone Collector

    Collect 100 soulstones.
    31%
33. 
    Soulstone Master

    Collect 500 soulstones.
    0.0%
34. 
    Rare Find

    Find a legendary tier chest.
    7.6%
35. 
    Completionist

    Unlock all soulstone types.
    7.6%
36. 
    Melee Specialist

    Complete 10 floors using only melee weapons.
    31%
37. 
    Magic Adept

    Complete 10 floors using only soulstone abilities.
    31%
38. 
    Speedrunner

    Complete a floor in under 2 minutes.
    100%
39. 
    Methodical

    Complete a floor without running (walking only).
    100%
40. 
    Pacifist

    Complete a floor killing only one enemy.
    100%
41. 
    Berserker

    Complete a floor without using any healing items.
    100%
42. 
    Merchant Friend

    Purchase 100 items from merchants.
    46%
43. 
    Minimalist

    Complete a floor carrying less than 25% of inventory
    100%
44. 
    Hoarder

    Complete a floor at 100% inventory capacity
    46%
45. 
    Perfectionist

    Complete a floor with 100% secrets found.
    7.6%
46. 
    Deep Delver

    Reach floor 10.
    100%
47. 
    Abyss Walker

    Reach floor 20.
    85%
48. 
    Void Traveler

    Reach floor 50.
    38%
49. 
    Endless Champion

    Reach floor 100.
    38%
50. 
    Master of the Endless Descent

    Complete the ultimate challenge.
    31%

Names, descriptions and icons are the game’s own, as Steam publishes them; the share is how many owners have unlocked each, from Steam's global figures for 50 of them.