For players of the previous installment or those curious, here is a quick rundown of the changes made.
DUO

Senko 2 (international art)

Overall
- More bullets/effects & gameplay has been sped up.
- Removed 'parameter strengthening' partner type.
- Streamlined the partner system: now pilot and partner are preset.
- Melee combo attacks now favour the person who hits first (simultaneous hits will cancel each other out).
Extra Abilities
- Added an ability to each partner, giving a wider range to use.
- Abilities can now be used multiple times in one round (once gauge has recovered).
Shot
- Removed compulsory reload allowing for continual fire.
Barrier/Shield
- Barrier now provides full protection from all but a few attacks (beams & napalm).
- Main melee attack and Bullet Canceller attacks can now be guarded.
Charge Gauge
- Gauge can now be recharged by picking up items as well.
- Items are dropped when doing damage to an opponent or destroying enemy projectiles/drones etc.
- Using Bullet Canceller to cancel an opponent's attacks also drops items.
Once gauge is empty, your mech overheats disabling barrier, Barrage Attack and B.O.S.S. mode.Melee Attacks
- Adjusted melee attack motions so they would 'home in' on an opponent and thus connect easier.
- Normal Bullet Cancellers can be cancelled into a dash.
B.O.S.S. Mode
- Removed bonus to Armour Gauge after exiting B.O.S.S. mode.
- Removed reduction to armour gauge when using an SP attack in B.O.S.S. mode.
Via developer G.Rev's official blog (Japanese only).